CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma.
Identifieur interne : 001012 ( Main/Exploration ); précédent : 001011; suivant : 001013CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma.
Auteurs : Bernard Escudier [France] ; Padmanee Sharma [États-Unis] ; David F. Mcdermott [États-Unis] ; Saby George [États-Unis] ; Hans J. Hammers [États-Unis] ; Sandhya Srinivas [États-Unis] ; Scott S. Tykodi [États-Unis] ; Jeffrey A. Sosman [États-Unis] ; Giuseppe Procopio [Italie] ; Elizabeth R. Plimack [États-Unis] ; Daniel Castellano [Espagne] ; Howard Gurney [Australie] ; Frede Donskov [Danemark] ; Katriina Peltola [Finlande] ; John Wagstaff [Royaume-Uni] ; Thomas C. Gauler [Allemagne] ; Takeshi Ueda [Japon] ; Huanyu Zhao [États-Unis] ; Ian M. Waxman [États-Unis] ; Robert J. Motzer [États-Unis]Source :
- European urology [ 1873-7560 ] ; 2017.
Abstract
The randomized, phase 3 CheckMate 025 study of nivolumab (n=410) versus everolimus (n=411) in previously treated adults (75% male; 88% white) with advanced renal cell carcinoma (aRCC) demonstrated significantly improved overall survival (OS) and objective response rate (ORR).
DOI: 10.1016/j.eururo.2017.02.010
PubMed: 28262413
Affiliations:
- Allemagne, Australie, Danemark, Espagne, Finlande, France, Italie, Japon, Royaume-Uni, États-Unis
- Californie, Communauté de Madrid, Lombardie, Maryland, Massachusetts, New Jersey, Pennsylvanie, Tennessee, Texas, Washington (État), État de New York
- Madrid, Milan
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Electronic address: escudier@gustaveroussy.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Padmanee" sort="Sharma, Padmanee" uniqKey="Sharma P" first="Padmanee" last="Sharma">Padmanee Sharma</name><affiliation wicri:level="2"><nlm:affiliation>MD Anderson Cancer Center, University of Texas, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>MD Anderson Cancer Center, University of Texas, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Mcdermott, David F" sort="Mcdermott, David F" uniqKey="Mcdermott D" first="David F" last="Mcdermott">David F. 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Electronic address: escudier@gustaveroussy.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Padmanee" sort="Sharma, Padmanee" uniqKey="Sharma P" first="Padmanee" last="Sharma">Padmanee Sharma</name><affiliation wicri:level="2"><nlm:affiliation>MD Anderson Cancer Center, University of Texas, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>MD Anderson Cancer Center, University of Texas, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Mcdermott, David F" sort="Mcdermott, David F" uniqKey="Mcdermott D" first="David F" last="Mcdermott">David F. Mcdermott</name><affiliation wicri:level="2"><nlm:affiliation>Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="George, Saby" sort="George, Saby" uniqKey="George S" first="Saby" last="George">Saby George</name><affiliation wicri:level="2"><nlm:affiliation>Roswell Park Cancer Institute, Buffalo, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Roswell Park Cancer Institute, Buffalo, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hammers, Hans J" sort="Hammers, Hans J" uniqKey="Hammers H" first="Hans J" last="Hammers">Hans J. Hammers</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Srinivas, Sandhya" sort="Srinivas, Sandhya" uniqKey="Srinivas S" first="Sandhya" last="Srinivas">Sandhya Srinivas</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Cancer Institute, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Cancer Institute, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tykodi, Scott S" sort="Tykodi, Scott S" uniqKey="Tykodi S" first="Scott S" last="Tykodi">Scott S. Tykodi</name><affiliation wicri:level="2"><nlm:affiliation>University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Sosman, Jeffrey A" sort="Sosman, Jeffrey A" uniqKey="Sosman J" first="Jeffrey A" last="Sosman">Jeffrey A. Sosman</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt University Medical Center, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Procopio, Giuseppe" sort="Procopio, Giuseppe" uniqKey="Procopio G" first="Giuseppe" last="Procopio">Giuseppe Procopio</name><affiliation wicri:level="3"><nlm:affiliation>Fondazione Istituto Nazionale Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione Istituto Nazionale Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Plimack, Elizabeth R" sort="Plimack, Elizabeth R" uniqKey="Plimack E" first="Elizabeth R" last="Plimack">Elizabeth R. Plimack</name><affiliation wicri:level="2"><nlm:affiliation>Fox Chase Cancer Center, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fox Chase Cancer Center, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Castellano, Daniel" sort="Castellano, Daniel" uniqKey="Castellano D" first="Daniel" last="Castellano">Daniel Castellano</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Universitario 12 De Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario 12 De Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Gurney, Howard" sort="Gurney, Howard" uniqKey="Gurney H" first="Howard" last="Gurney">Howard Gurney</name><affiliation wicri:level="1"><nlm:affiliation>Westmead Hospital, Westmead, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Westmead Hospital, Westmead, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Donskov, Frede" sort="Donskov, Frede" uniqKey="Donskov F" first="Frede" last="Donskov">Frede Donskov</name><affiliation wicri:level="1"><nlm:affiliation>Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Peltola, Katriina" sort="Peltola, Katriina" uniqKey="Peltola K" first="Katriina" last="Peltola">Katriina Peltola</name><affiliation wicri:level="1"><nlm:affiliation>Comprehensive Cancer Center, Helsinki University Central Hospital Cancer Center, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Comprehensive Cancer Center, Helsinki University Central Hospital Cancer Center, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Wagstaff, John" sort="Wagstaff, John" uniqKey="Wagstaff J" first="John" last="Wagstaff">John Wagstaff</name><affiliation wicri:level="1"><nlm:affiliation>South West Wales Cancer Institute and Swansea University College of Medicine, Swansea, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>South West Wales Cancer Institute and Swansea University College of Medicine, Swansea</wicri:regionArea><wicri:noRegion>Swansea</wicri:noRegion></affiliation></author><author><name sortKey="Gauler, Thomas C" sort="Gauler, Thomas C" uniqKey="Gauler T" first="Thomas C" last="Gauler">Thomas C. Gauler</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Essen of University of Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Essen of University of Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Ueda, Takeshi" sort="Ueda, Takeshi" uniqKey="Ueda T" first="Takeshi" last="Ueda">Takeshi Ueda</name><affiliation wicri:level="1"><nlm:affiliation>Chiba Cancer Center, Chiba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba Cancer Center, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Huanyu" sort="Zhao, Huanyu" uniqKey="Zhao H" first="Huanyu" last="Zhao">Huanyu Zhao</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Waxman, Ian M" sort="Waxman, Ian M" uniqKey="Waxman I" first="Ian M" last="Waxman">Ian M. Waxman</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Motzer, Robert J" sort="Motzer, Robert J" uniqKey="Motzer R" first="Robert J" last="Motzer">Robert J. Motzer</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">European urology</title><idno type="eISSN">1873-7560</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The randomized, phase 3 CheckMate 025 study of nivolumab (n=410) versus everolimus (n=411) in previously treated adults (75% male; 88% white) with advanced renal cell carcinoma (aRCC) demonstrated significantly improved overall survival (OS) and objective response rate (ORR).</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Italie</li><li>Japon</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Californie</li><li>Communauté de Madrid</li><li>Lombardie</li><li>Maryland</li><li>Massachusetts</li><li>New Jersey</li><li>Pennsylvanie</li><li>Tennessee</li><li>Texas</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Madrid</li><li>Milan</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Escudier, Bernard" sort="Escudier, Bernard" uniqKey="Escudier B" first="Bernard" last="Escudier">Bernard Escudier</name></noRegion></country><country name="États-Unis"><region name="Texas"><name sortKey="Sharma, Padmanee" sort="Sharma, Padmanee" uniqKey="Sharma P" first="Padmanee" last="Sharma">Padmanee Sharma</name></region><name sortKey="George, Saby" sort="George, Saby" uniqKey="George S" first="Saby" last="George">Saby George</name><name sortKey="Hammers, Hans J" sort="Hammers, Hans J" uniqKey="Hammers H" first="Hans J" last="Hammers">Hans J. Hammers</name><name sortKey="Mcdermott, David F" sort="Mcdermott, David F" uniqKey="Mcdermott D" first="David F" last="Mcdermott">David F. Mcdermott</name><name sortKey="Motzer, Robert J" sort="Motzer, Robert J" uniqKey="Motzer R" first="Robert J" last="Motzer">Robert J. Motzer</name><name sortKey="Plimack, Elizabeth R" sort="Plimack, Elizabeth R" uniqKey="Plimack E" first="Elizabeth R" last="Plimack">Elizabeth R. Plimack</name><name sortKey="Sosman, Jeffrey A" sort="Sosman, Jeffrey A" uniqKey="Sosman J" first="Jeffrey A" last="Sosman">Jeffrey A. Sosman</name><name sortKey="Srinivas, Sandhya" sort="Srinivas, Sandhya" uniqKey="Srinivas S" first="Sandhya" last="Srinivas">Sandhya Srinivas</name><name sortKey="Tykodi, Scott S" sort="Tykodi, Scott S" uniqKey="Tykodi S" first="Scott S" last="Tykodi">Scott S. Tykodi</name><name sortKey="Waxman, Ian M" sort="Waxman, Ian M" uniqKey="Waxman I" first="Ian M" last="Waxman">Ian M. Waxman</name><name sortKey="Zhao, Huanyu" sort="Zhao, Huanyu" uniqKey="Zhao H" first="Huanyu" last="Zhao">Huanyu Zhao</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Procopio, Giuseppe" sort="Procopio, Giuseppe" uniqKey="Procopio G" first="Giuseppe" last="Procopio">Giuseppe Procopio</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Castellano, Daniel" sort="Castellano, Daniel" uniqKey="Castellano D" first="Daniel" last="Castellano">Daniel Castellano</name></region></country><country name="Australie"><noRegion><name sortKey="Gurney, Howard" sort="Gurney, Howard" uniqKey="Gurney H" first="Howard" last="Gurney">Howard Gurney</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Donskov, Frede" sort="Donskov, Frede" uniqKey="Donskov F" first="Frede" last="Donskov">Frede Donskov</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Peltola, Katriina" sort="Peltola, Katriina" uniqKey="Peltola K" first="Katriina" last="Peltola">Katriina Peltola</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Wagstaff, John" sort="Wagstaff, John" uniqKey="Wagstaff J" first="John" last="Wagstaff">John Wagstaff</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Gauler, Thomas C" sort="Gauler, Thomas C" uniqKey="Gauler T" first="Thomas C" last="Gauler">Thomas C. Gauler</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Ueda, Takeshi" sort="Ueda, Takeshi" uniqKey="Ueda T" first="Takeshi" last="Ueda">Takeshi Ueda</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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